The bottom line for this article is that I want to make WordPress as fast, secure, and easy to install, run, and manage because I am using it more and more for client production sites, I will work for days in order to solve an issue so that I never have to spend time on that issue again. Time is money in this industry and that is ultimately (time) what there is to gain by tweaking WordPress.
Note: I spent no time on readability, this is primarily a read the code and figure it out article.. This is for advanced users looking for a reference or discussion and for those of you looking to advance. Feedback would be great if you make it that far..